CMS proposed OPPS and ASC payment changes aimed at affordability for Medicare beneficiaries, with a focus on drug payment policy, site-of-care incentives, and lower out-of-pocket costs. The agency highlights 340B drug payment changes and projected savings for Medicare and taxpayers, alongside reforms intended to reduce incentives that can make hospital outpatient care more expensive. The proposal is significant on cost because it combines beneficiary affordability with federal savings and provider payment redesign.